Excerpt from my book Silica Water the Secret to Healthy Longevity in the Aluminum Age.
https://www.amazon.com/Dennis-N-Crouse-Ph-D/e/B01LFW4782?ref=sr_ntt_srch_lnk_1&qid=1579731438&sr=8-1
Preventing Alzheimer’s Disease in Those with Down Syndrome
Children with Down syndrome
have delayed growth, characteristic physical traits, and mild to moderate
intellectual disability. Down syndrome (a.k.a. trisomy 21) is a genetic
disorder involving the presence of all or part of a third copy of chromosome 21394.
The extra chromosome occurs by chance with the parents of a Down child being
genetically normal. The possibility of
giving birth to a Down child is 0.1% in mothers 20 years old and 3% in mothers
45 years old. Currently there is no known environmental factor that changes
these percentages.
Environmental factors do lead
to earlier onset of AD in those with Down syndrome. There is a six-fold
increased gastrointestinal absorption of aluminum in individuals with Down
syndrome395. This is likely why 90% of those with Down syndrome over
30 years of age have similar neuropathology to Alzheimer’s disease (AD)
patients and at least 70% will develop dementia by age 55 to 60 years395,396.
In general as they age,
people absorb and accumulate aluminum at different rates accounting for why
some get AD earlier than others77,397. On average people under 77 years of age
diagnosed with AD have a 64% greater gastrointestinal aluminum absorption rate
than age-matched people without AD398,399. But on average all people
over 77 years of age, with and without AD, have similar high rates of
gastrointestinal aluminum absorption400. The major difference
between AD patients with and without Down syndrome is an earlier onset of both
gastrointestinal aluminum absorption and AD neuropathology in those with Down
syndrome401.
Conclusion of Preventing Alzheimer’s in those
with Down Syndrome - Aluminum does not cause Down syndrome but aluminum absorption is
six-fold greater in individuals with Down syndrome than normal. This high level of aluminum absorption
increases the risk of Alzheimer’s in those with Downs resulting in 70% of those
with Down syndrome developing dementia by age 55 to 60 years of age. In order
to prevent Alzheimer’s it is recommended that those with Down syndrome take a
daily OSA rich silica water supplement.
In addition a diet high in silica rich vegetables and grains is
recommended.
77. Edwardson, J.A., et al.; Effect of silicon on gastrointestinal
absorption of aluminum; The Lancet; 342(8865):211-12 (1993)
395.Moore, P.B., et al.; Gastrointestinal absorption of
aluminum is increased in Downs syndrome; Biol. Psychiatry; Feb.;
15:41(4):488-92 (1997)
396.Lai, F. and Williams,
R.S.; A prospective study of Alzheimer’s disease in Down syndrome; Arch
Neurol.; 46:849-53 (1989)
397.Wilcock, D.M., and
Griffin, W.S.; Down’s syndrome, neuroinflammation and Alzheimer’s
neuropathogenesis; J. Neuroinflammation; 10:84 (2013)
398.House, E., et al.;
Aluminum, iron, and copper in human brain tissues donated to the Medical
Research Council’s cognitive functioning and ageing study; Metallomics; Jan. 4(1):56-65 (2012)
399.Moore, P.B.; et al.;
Absorption of aluminum-26 in Alzheimer’s disease, measured using accelerator
mass spectrometry; 11:66-69 (2000)
400.Taylor, G.A., et al.;
Gastrointestinal absorption of aluminum in Alzheimer’s disease: response to
aluminum citrate; Age Ageing; Mar.; 21(2):81-90 (1992)
401.Hartley, D., et al.; Down
syndrome and Alzheimer’s disease: Common pathways and common goals; Alzheime’s
Dement.; June; 11(6):700-709 (2015)
402.
