Neurons and Exercise

Neurons and Exercise

Sunday, February 23, 2020

Multiple Sclerosis - Silica water for healing


This an an excerpt from the book:  

Silica Water the Secret of Healthy Blue Zone Longevity in the Aluminum Age by Dr. Dennis N Crouse 

This book is available on Amazon    link to book on Amazon


Multiple Sclerosis

Multiple sclerosis (MS) is a demyelinating disease in which demyelination of nerve cell axons occurs in the central nervous system (i.e. spinal cord and brain). Myelin sheaths on nerve cell axons electrically insulate the axons allowing them to very quickly transfer impulses. Oligodendrocytes are a type of glial cells that create myelin sheaths. Environmental chemicals that disrupt the biochemistry of oligodendrocytes will cause inflammatory demyelination lesions on axons, interference of axonal nerve conduction, and ultimately multiple sclerosis with a range of symptoms including physical, mental, and sometimes psychiatric problems. Cognitive impairment occurs in up to 65 percent of those with MS346. The specific symptoms of MS depend upon the location of the inflammatory lesions in the nervous system. MS is triggered by both environmental and genetic factors that increase the individual’s risk of MS347.
MS was first described in 1868 by Jean-Martin Charcot348. Approximately 2.3 million people worldwide were affected by MS in 2015 and 18,900 people died of MS worldwide in 2015 compared with 12,000 people in 1990349. MS is usually diagnosed between 20 to 50 years of age being most commonly diagnosed at age 30. Twelve twin pairs with identical genetics (i.e. monozygotic) were given a firm clinical diagnosis of MS in one or both twins. In 6 twin pairs only one twin had MS and in the other 6 twin pairs both twins had MS350. This suggests that the causes of MS include both environmental and genetic factors.
In 1980 the prevalence of MS was shown to have a strong dependence on the latitude at which people were living351. The number of deaths per year due to MS is a good indication of the prevalence of MS and this is shown globally in Figure 28349. Migration studies indicated that adult migrants generally retained the MS risk of their birthplace. However, it was found that those migrating under 15 years of age by moving either closer of further from the equator acquired the risk of their new residence351. A review in 2008 revealed that in the previous 30 years the MS incidence was both less dependent upon latitude and from 1955 to 2008 the female MS to male MS ratio had increased during this period from 1.4 to 2.3352.
     
Figure 28 – Deaths from multiple sclerosis as a function of latitude in 2012349
The latitude dependence of MS is similar to that of autism in that both diseases are found at lower prevalence in the tropics351,353.  Since the production of vitamin D3 in the body requires sunlight and there is more sunlight per day in the tropics, it has been theorized that vitamin D3 may play a role in preventing autism and possibly MS354. This role could be due to vitamin D’s facilitation of aluminum elimination by the kidneys, even in children with chronic kidneys damage355. 
Although multiple sclerosis and autism have the same latitudinal dependence, the female to male ratio of those diagnosed with MS is the inverse of that observed in autism. It is known that young boys absorb more aluminum than young girls possibly accounting for why there are 4 times more boys than girls who are diagnosed with autism128,129.  However MS is a disease of women and men not young girls and boys. Women who are pregnant have almost no silica in their blood making them more likely to accumulate aluminum (see Figure 8) 85. It is known that women who have unrecognized MS will start having MS symptoms during pregnancy or after delivery when they have almost no silica in their blood356.  Also, up to 40% of women with relapsing-remitting MS will have a relapse after pregnancy357.  This data agrees with the hypothesis that low silica in the blood during pregnancy results in more aluminum accumulation and MS symptoms in women.
The incidence rate of MS is rising at a rate faster than accounted for by either a genetic mutation moving through the population or improved testing for MS358.  Three studies have been published that examined the temporal variation in MS incidence rates and the female to male MS ratio and the data is presented in Table 31 and Figure 29359-361.   
 Table 31. MS Incidence Rates and Female to Male MS Ratios359-361
Location
Latitude
Years
MS Incidence
(per 100,000)
Female to Male
MS Ratio
Ref.
S.E. Wales, U.K.
51oN
2006
7.30
4.3
359


1983
2.65
1.8







Newcastle, Australia
33oS
2001-2011
6.70
3.1
360


1986-1996
2.45
2.0



1971-1981
2.14
-







Tehran Province, Iran
36oN
2005-2006
5.68
3.1
361


1989
0.68
-


All three of these areas of the world have seen a dramatic increase in MS incidence in the last 20 to 30 years.  Note that S.E. Wales is furthest from the equator and it does have both a slightly higher MS incidence rate and a higher female to male ratio than the other two locations.  
             
Figure 29 – MS Incidence Rates and Worldwide Aluminum Production227-229, 359-361
In the thirty year period from 1975 to 2005 the MS incidence rate of both S.E. Wales and Newcastle Australia increased three-fold359,360.  During this same period worldwide aluminum production also increased three-fold. This rise in aluminum production has resulted in higher aluminum ingestion due to aluminum being added to drinking water, food, kitchen ware, drugs, vaccines, colored candy, and even inhaled air. These products increase both aluminum ingestion and aluminum accumulation in our bodies.  
Multiple sclerosis is a demyelinating disease and myelin is made by cells called oligodendrocytes. Aluminum negatively impacts myelin production by promoting the peroxidation of myelin in oligodendrocytes363,364.  Transferrin is a molecular iron transporter required by the body to move iron across the blood-brain-barrier.  Aluminum can mimic iron due to similar size and ionic charge.  Therefore aluminum can be transported into oligodendrocytes by transferrin.  When aluminum complexed with transferrin is incubated with oligodendrocytes there is a 3 to 4 fold increase in aluminum inside oligodendrocytes362.   
Table 32 - Metal Ion Induction of ROS in Human Glial Cells219
Metal Sulfate
Relative Induction of ROS
Aluminum
10
Iron
6
Manganese
4.5
Zinc
4
Nickel
3.5
Lead
3.5
Gallium
3
Copper
3
Cadmium
3
Tin
2
Mercury
1.5
Magnesium
0
Sodium
0

Myelin is the preferential target of aluminum-mediated oxidative damage363,364. This oxidation occurs due to aluminum ions being transported by transferrin into glial cells, specifically oligodendrocytes364. Aluminum ions act as physiological stressors by stimulating brain cells to produce oxidizing chemicals (a.k.a. ROS) that cause inflammation in the brain219,365,366. Table 32 shows how much ROS is produced from a cell culture of human glial cells exposed to 50nM aqueous solutions of various common metal ions219. 
As shown in Table 32 aluminum tops the list of metal ion inducers of reactive oxygen species (ROS) in human glial cells, like oligodendrocytes.  Aluminum at very low concentration (i.e. nanomolar) has also been shown to induce pro-inflammatory gene expression in human brain cells366.  The accumulation of aluminum in oligodendrocytes causing inflammatory lesions is a likely causal factor of MS. 
Chris Exley’s group at Keele University has shown that people with MS have a higher than normal body burden of aluminum. They have also shown that OSA rich drinking water facilitates aluminum elimination in those with MS. The median daily aluminum excretion in the urine of people with relapsing-remitting and secondary progressive MS is 7.4 and 2.6 times higher, respectively, than people without MS367. The amount of aluminum excreted by those with relapsing–remitting MS was twice as high as people suffering aluminum intoxication. The median aluminum excretion in the urine of 14 out of 15 people with MS was found to 2.5 fold higher when drinking up to 1.5 liters of silica-rich water (35ppm OSA) per day with women excreting more aluminum than men368.  Therefore people with MS absorb and accumulate more aluminum than normal and silica water facilitates aluminum elimination in those with MS.
But do people with MS accumulate more aluminum in their brains than normal? This question was recently answered by Chris Exley’s group at Keele University369. They analyzed brain tissue from 14 donors with a diagnosis of MS for aluminum. They found that the aluminum content of brain tissue in those with MS was “universally high” with many tissues bearing concentrations in excess of 10mcg/gram dry weight and some exceeding 50mcg/gram dry weight, while 1mcg/gram dry weight is considered normal. Aluminum specific staining showed aluminum both inside and outside of cells369.  
These results indicate that people with MS have a higher body-burden of aluminum than normal and some of that aluminum is in their brains at much higher than normal levels. Drinking silica-rich water facilitates the elimination of aluminum and possibly ultimately lowers the frequency of relapsing or slows the progression of MS.


There is limited anecdotal information available regarding OSA treatment for MS. But in 2014 a book was published titled the “The Wahls Protochol” written by Dr. Terry Wahls, M.D. 454. Dr. Wahls was diagnosed with MS eventually requiring a wheelchair. But then miraculously she healed herself. She can now ride her bike as much as 18 miles in a day. This brings to my mind the biblical phrase: “Physician heal thyself” (Luke 4:23 King James Version).  She changed her diet and a number of lifestyle choices that both increased OSA ingestion and decreased aluminum ingestion and accumulation for example:
·         Consumed at least 6-9 cups of vegetables a day – Increases OSA ingestion (see Table 23)
·         Consumed much more vegetables than fruit – Increases OSA ingestion (see Table 23)
·         Added fermented vegetables to the diet – Increases OSA ingestion
·         Reduced protein in the diet – Increases OSA ingestion due to substituting vegetables
·         Switched to stainless steel and cast iron cookware – Lowers aluminum ingestion
·         Used sauna 4 times a week – Facilitates aluminum elimination that is enhanced with OSA
·         Performed daily aerobic exercise – Increases hippocampal volume and produces more neuropeptide YY (a.k.a. PYY) that lowers aluminum absorption and accumulation1.

MS Due to Vaccine Injury

The human papilloma vaccine (a.k.a. HPV, Gardasil) contains aluminum as an adjuvant and is given as a series of vaccinations to people aged 9 to 44.  The HPV vaccine is primarily given to people at an age when they have the highest risk of MS.
   
In 2015 a Scandinavian study of 4 million girls and women age 10 to 44, of whom 800,000 were given the HPV vaccination, reported no statistically significant increased risk of MS370.  Of the 4 million eligible for the study 5,553 individuals were excluded “because of prevalent multiple sclerosis” and 4,322 individuals were first diagnosed with MS during the study. However, of the 800,000 who received the HPV vaccination only 73 were diagnosed with MS during a 2 year period following HPV vaccination. However, 30 to 44 year olds who were given the HPV vaccine were shown to have a slightly increased risk of MS diagnosis within 2 years of vaccination compared to those who did not receive the vaccine (40/100,000 versus 30/100,000).
The Scandinavian study did not evaluate the risk of a relapse of MS symptoms due to the HPV vaccine in those 5,553 people who were excluded “because of prevalent multiple sclerosis”. These 5,553 girls and women are most likely to be both aluminum absorbers and negatively impacted by HPV vaccination. For instance, relapse of MS symptoms, for those diagnosed with relapsing-remitting MS, is likely triggered by either high levels of aluminum and/or low levels of silica in their blood. A study is needed to evaluate the risk of relapse after vaccination with an aluminum containing vaccine in those people diagnosed with relapsing-remitting MS. Currently the MS Trust in the U.K. recommends, if you are experiencing a relapse affecting your ability to carry out daily living activities, delay vaccination until your symptoms are resolved.       

In 2018 in Miami, Florida two teens, one male and one female, who were 14 and 17 years of age experienced symptoms of MS within 1 to 2 weeks of vaccination with HPV vaccine371. They both were diagnosed with optic neuritis and had symptoms of blurred vision and in one case numbness and weakness in the legs. Oliogoclonal bands (i.e. bands of immunoglobulins) were found in their cerebrospinal fluid but not their blood serum indicating inflammation of the central nervous system that is indicative of MS. Both teens experienced a relapse of symptoms within 2 months of initial symptoms and were both diagnosed with relapsing–remitting MS371. 

MS is a disease with “obscure symptoms” 371. Therefore MS may fail to be correctly diagnosed in all cases. In the following anecdotal information from Facebook we may have an example of undiagnosed relapsing-remitting MS. Possibly due to both childhood vaccinations with aluminum containing vaccines and a diet of junk food and healed by drinking silica water and avoiding junk food:
“My son has always been healthy, and I cannot remember a time where he has needed to go to the doctor in all of his 10 years.  But at age 10 he went from healthy to wheelchair bound in the space of 6 months. First he had blurred vision and I noticed he was walking too close to walls and hedges, almost walking into them.  Then he had chronic weakness in his legs and would fall over, unable to move his legs. He was tested and they found nothing wrong, believing it must be a mental problem. After all these tests he remained undiagnosed, untreated, and continued to deteriorate physically and mentally. I researched and followed Chris Exley's advice, giving my son Volvic silica water each day. We noticed a difference within 3 days, he was out of the wheelchair within 10 days, and doing PE and gymnastics at school in 45 days. A relapse of symptoms happened recently. Unfortunately when my son strays off the healthy food and eats junk food over a certain amount of time, his symptoms reappear. Doctors don't want to admit that they failed and a daily bottle of silica water cured him. He has been on Volvic water since November 2016. This is something we will do for as long as we can. It is not a quick fix and needs to be a lifestyle change. Sorry to say it, the health system failed us, but Prof Exley's research saved our son. It sounds too simple to be true, but it worked unquestionably for us.”  August 2018 
Note that the symptoms in this anecdotal case (i.e. blurred vision, weakness in the legs, relapse of symptoms) are identical to those observed recently in Florida after HPV vaccination. These are likely examples of aluminum in vaccines and/or aluminum in junk food triggering MS or a relapse of MS symptoms. For more information on aluminum containing junk food to avoid and vaccines that contain aluminum see Appendix II and III. 
Conclusion of Multiple Sclerosis - MS is a demyelinating disease that slows nerve impulses on nerve cell axons. The myelin that coats the outside of axons and associated glial cells (e.g. oligodendrocytes) that make myelin are targets for aluminum accumulation and toxicity363-364. In several areas of the world the incidence of MS is rising at the same rate as world-wide aluminum production227-229, 359-361. Aluminum ions are known to damage glial cells by stimulating the production of reactive oxygen species (ROS) 365. ROS induced inflammation of glial cells results in inflammatory lesions that are characteristic of MS347.
Compared with those without MS, people with relapsing-remitting MS have 7-fold more aluminum and people with secondary progressive MS have 2.6-fold more aluminum in their urine on average367.  Also people with MS have much higher than normal concentrations of accumulated aluminum in their brains369. Silica-rich drinking water has been shown to increase aluminum excretion in the urine by 2.5-fold in those with MS368.
Further research is needed to find if a steady diet of silica-rich drinking water and/or OSA rich vegetables will lower the frequency of relapsing or the slow the progression of MS.